The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Renin–angiotensin–aldosterone system inhibitors in patients with COVID-19. Vaduganathan M., Vardeny O., Michel T., McMurray J.J.V., Pfeffer M.A., Solomon S.D. Can symptoms of anosmia and dysgeusia be diagnostic for COVID-19? Brain Behav. Zahra S.A., Iddawela S., Pillai K., Choudhury R.Y., Harky A. Clinical features of COVID-19 and influenza: a comparative study on Nord Franche-Comte cluster. Zayet S., Kadiane-Oussou N.J., Lepiller Q., Zahra H., Royer P.Y., Toko L. Natural history of disease can be well established by cohort study As these studies are costly and laborious, understanding natural history of disease is largely based on other epidemiological studies such as cross sectional and retrospective studies. Fifteen patients had a respiratory rate ≥22/min on day 9 (☐.8) and only 8 patients (15%) were admitted or transferred in an ICU on day 10 (☒.7) with a mean duration of hospitalization in ICU of 7.9 (☖.6 ) days.ĬOVID-19 Clinical features coronavirus evolution history symptoms timeline wave. Twenty-three patients (32.9%) required oxygen therapy 6.7 (±4.1 ) days from illness onset. Thirty three patients (47.1%) were hospitalized on day 7 (☓) with a mean duration of hospitalization of 6.9 (±5.8 ) days. Firstly, pain syndrome defined by headache and/or myalgia and/or arthralgia (87%, n = 61) appeared as the first manifestation 1.6 day after the onset of the illness. We retrospectively reconstituted the history of evolution and onset of the main symptoms of COVID-19 in 70 patients ( with a mean age of 56.7 ± 19.3 years).
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